What are High Histamines?

woman with headache

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My health journey over the past couple of years has been… interesting to say the least. Following a couple of years of high-stress levels, I developed food allergies, a gluten intolerance, and health problems that have caused me to need a nap every day and feel like I’m slogging through wet laundry as I go through my daily routine.

All of this led me to learn and get tested for Pyroluria which brought me to Dr. Mensah who is a specialist in the field of methylation and Pyroluria, among other things.

A year ago, I didn’t even know such things existed and I bet you have no idea what they are either. Why would you, when all of the conditions I’ve mentioned are treated with nutritional supplements, not pharmaceuticals?

I don’t fully understand high histamines/methylation. Things get very technical when you talk about molecular science and cells and methyl.

Here’s an explanation in terms we can (sort of) all  understand:

Simply put, methylation is a chemical reaction that occurs in every cell and tissue in your body. Chemically speaking, methylation is the process of adding methyl groups to a molecule.

A ‘methyl group’ is a chemical structure made of one carbon and three hydrogen atoms. Since methyl groups are chemically inert, adding them to a protein (the process of methylation) changes how that protein reacts to other substances in the body, thus affecting how that protein behaves. Enzymes, hormones, and even genes are proteins and the process of methylation affects them all.

In some ways, methylation of proteins helps the body detoxify. For example, the methylation process helps convert the toxic amino acid (homocysteine) into a beneficial amino acid (methionine). If your body cannot methylate properly, toxins build up in your bloodstream and will eventually cause disease. source

To make a long story short, after being tested for Pyroluria and consulting with Dr. Mensah, he ordered a copper test and one for histamines too. I learned that I had extremely high histamine levels, double what people should have.

So…what does that mean?

Obsessive-compulsive disorder, seasonal depression (SAD) or allergies, defiance, perfectionism. These are just some of the traits that can be related to undermethylation – which may be a result of elevated histamine levels

For the low down on histamine, check out holistichelo.net

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